Human Genome in Health and Disease
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Naturwissenschaften, Medizin, Informatik, Technik / Nichtklinische Fächer
The human genome is a linear sequence of roughly 3 billion bases and information regarding this genome is accumulating at an astonishing rate. Inspired by these advances, The Human Genome in Health and Disease: A Story of Four Letters explores the intimate link between sequence information and biological function. A range of sequence-based functional units of the genome are discussed and illustrated with inherited disorders and cancer. In addition, the book considers valuable medical applications related to human genome sequencing, such as gene therapy methods and the identification of causative mutations in rare genetic disorders.The primary audiences of the book are students of genetics, biology, medicine, molecular biology and bioinformatics. Richly illustrated with review questions provided for each chapter, the book helps students without previous studies of genetics and molecular biology. It may also be of benefit for advanced non-academics, which in the era of personal genomics, want to learn more about their genome. Key selling features:Molecular sequence perspective, explaining the relationship between DNA sequence motifs and biological functionAids in understanding the functional impact of mutations and genetic variantsMaterial presented at basic level, making it accessible to students without previous studies of genetics and molecular biologyRichly illustrated with questions provided to each chapter