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Glutathione and Sulfur Amino Acids in Human Health and Disease

Giuseppe Mazza, Roberta Masella

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John Wiley & Sons img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Organische Chemie

Beschreibung

The complex roles of glutathione and sulfur amino acids in human health Glutathione (gamma-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others. This book provides researchers with a comprehensive review of the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids. The twenty-two chapters explore such topics as: * Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids * Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses * Biological activities of GSH and sulfur amino acids and their role in modulating cell processes * Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging * Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animals Special attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models. With more than 2,000 scientific references, this book provides food scientists, nutritionists, biochemists, food technologists, chemists, molecular biologists, and public health professionals with a comprehensive and up-to-date examination of glutathione and sulfur amino acids in human health and disease.

Rezensionen

The book is a valuable resource material for those who have an interest, either professionally or scientifically, in all kinds of disorders in the human body caused by deficiency of glutathione and sulfur amino acids.
"

The chapters are very well organized, which gives a direct and well presented answer to those who need any information on specific topics. In addition to that, the whole text displays scientific references in a way, which is easy to understand, even to those who do not have scientific background in this field."

--Prof. Vlasta Pili?ota, Ph.D., Faculty of Food Technology University of J.J. Strossmayer in Osijek, Croatia
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Schlagwörter

Chemistry, Biochemie, Biowissenschaften, Biochemistry (Chemical Biology), Chemie, Life Sciences, Zell- u. Molekularbiologie, Aminosäuren, Food Science & Technology, Biochemie u. Chemische Biologie, Cell & Molecular Biology, Lebensmittelforschung u. -technologie