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Preparation of Compounds Labeled with Tritium and Carbon-14

Rolf Voges, J. Richard Heys, Thomas Moenius, et al.

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John Wiley & Sons img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Organische Chemie


Compounds labeled with carbon-14 and tritium are indispensabletools for research in biomedical sciences, discovery anddevelopment of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium andCarbon-14 is a comprehensive, authoritative and up-to-datediscussion of the strategies, synthetic approaches, reactionstechniques, and resources for the preparation of compounds labeledwith either of these isotopes. A large number of examples arepresented for the use of isotopic sources and building blocks inthe preparation of labeled target compounds, illustrating the rangeof possibilities for embedding isotopic labels in selected moietiesof complex structures. Topics include: * Formulation of synthetic strategies for preparing labeledcompounds * Isotope exchange methods and synthetic alternatives forpreparing tritiated compounds * In-depth discussion of carbon-14 building blocks and theirutility in synthesis * Preparation of enantiomerically pure isotopically labeledcompounds * Applications of biotransformations Preparation of Compounds Labeled with Tritium andCarbon-14 is an essential guide to the specialist strategiesand tactics used by chemists to prepare compounds tagged withtheradioactive atoms carbon-14 and tritium.

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Methods - Synthesis & Techniques, Chemische Synthese, Wirkstoffforschung u. -entwicklung, Chemie, Chemistry, Organische Chemie / Methoden, Synthesen, Verfahren, Drug Discovery & Development, Arzneimittelentwicklung, Biochemie