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The Epigenetics of Autoimmune Diseases

Moncef Zouali (Hrsg.)

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John Wiley & Sons img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Genetik, Gentechnik


The role of epigenetic mechanisms in autoimmune disease is only nowstarting to become clear. Understanding these mechanisms, theireffect on cellular function and the role of environmental factorsis vital to determining how to manage these often debilitating andfatal diseases. Drawing on the research of leading experts, thisbook provides a valuable insight into this important new areaof autoimmunity research and a clear, up-to-date view on themajor advances in the field. Specific coverage includes: * How highly developed epigenetic mechanisms are involved inseveral aspects of normal immune regulation, in addition tomaintaining immune tolerance to self-determinants. * Specific epigenetic aspects of human autoimmune diseases,including multiple sclerosis, systemic lupus erythematosus,rheumatoid arthritis, systemic sclerosis, autoimmune diabetes,thyroid autoimmunity, inflammatory bowel disease and autoimmunehepatitis. * How understanding epigenetic mechanisms can lead to therapeuticstrategies based on manipulation of this previously unexploitedfacet of immune regulation. * Discussion of the novel approaches that are being investigatedto prevent or treat autoimmune diseases. This book is an essential resource for those activelyinvolved in the field. It is also of interest to basic researchersinterested in understanding the origin of autoimmunity and clinicalspecialists interested in gaining in-depth understanding of thepathogenesis of autoimmune diseases and their treatment.

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Zell- u. Molekularbiologie, Biowissenschaften, Medical Science, Genetik, Medizin, Immunology, Cell & Molecular Biology, Life Sciences, Immunologie, Genetics