The Molecular Switch
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Naturwissenschaften, Medizin, Informatik, Technik / Naturwissenschaften allgemein
A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.
Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.
Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.
Competitive inhibition, Enhancer (genetics), Bacteriorhodopsin, Allosteric modulator, Chemotaxis, Lac repressor, Biology, Kinetic theory of gases, Transcription factor, Calculation, Effector (biology), Adrenergic receptor, Optical tweezers, Archaea, EC50, Bohr effect, Ligand (biochemistry), Gene expression, Molecular recognition, Signal transduction, Degrees of freedom (mechanics), Structural biology, Anaphase, High-throughput screening, Proofreading (biology), Cryo-electron microscopy, Gillespie algorithm, Post-translational modification, Polymerase, Nucleotide, Active site, Chromatin, Renormalization, Statistical mechanics, Model organism, Action potential, Phosphofructokinase, Restriction enzyme, C0, Dissociation constant, Jacques Monod, Histone, Arginine, Acid–base homeostasis, Enzyme assay, Idealization, Ion Channels, Genomic DNA, Enzyme, Kinetic proofreading, Regulation of gene expression, Chemoreceptor, Ion channel, Probability, Chemical potential, Transcriptional regulation, Allosteric enzyme, Quorum sensing, Michaelis–Menten kinetics, Enzyme kinetics, Molecular biology, Statistical physics, Inducer, Exocytosis, Hemoglobin, Result, Sequencing, Glycolysis, Autoinducer, Cytosine, Molecule, Biochemistry, Hill equation (biochemistry), Statistical weight, Receptor (biochemistry), Conformational change, Escherichia coli, Biophysical chemistry, Metabolism, G protein, Molecular motor, Petri dish, Binding constant, Phosphodiesterase, Protein, Tryptophan repressor, Cooperativity, Triosephosphate isomerase, Peptide, Jean-Pierre Changeux, Mass spectrometry, Nucleosome, Repressor, Bacteria, Bicoid (gene), Enzyme inhibitor, Toy model, Phosphorylation, Robert Lefkowitz, Mitosis