img Leseprobe Leseprobe

The Molecular Switch

Signaling and Allostery

Rob Phillips

ca. 92,99
Amazon iTunes Hugendubel Bü kobo Osiander Google Books Barnes&Noble Legimi
* Affiliatelinks/Werbelinks
Hinweis: Affiliatelinks/Werbelinks
Links auf sind sogenannte Affiliate-Links. Wenn du auf so einen Affiliate-Link klickst und über diesen Link einkaufst, bekommt von dem betreffenden Online-Shop oder Anbieter eine Provision. Für dich verändert sich der Preis nicht.

Princeton University Press img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Naturwissenschaften allgemein


A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.

Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.

Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

Weitere Titel zum gleichen Preis
Cover Making Mice
Karen Rader
Cover The Light of the World
Joseph ibn Nahmias



Bohr effect, glycolosis, cyclic nucleotide gated channels, logic gates, allosterome, phoshofructokinase, Alexander Gann, Cell Signaling, MWC enzymes, nucleosomes, Tony Pawson, Genes and Signals, bacterial aerotaxis, enzyme phenomenology, Bruce Mayer, Michaelis-Menten Enzymes, ligand-receptor binding, Mark Ptashne, genome packing, membrane receptors, gene expression, Wendell Lim, signal transduction