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The Molecular Switch

Signaling and Allostery

Rob Phillips

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Princeton University Press img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Naturwissenschaften allgemein

Beschreibung

A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.

Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.

Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

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Schlagwörter

Robert Lefkowitz, Bacteria, Competitive inhibition, Degrees of freedom (mechanics), Histone, Regulation of gene expression, Molecule, Statistical mechanics, Allosteric modulator, G protein, Nucleosome, Jean-Pierre Changeux, Bicoid (gene), Dissociation constant, Phosphorylation, Signal transduction, Effector (biology), Metabolism, Biochemistry, Statistical weight, Jacques Monod, Molecular recognition, Renormalization, Kinetic theory of gases, Molecular biology, Enhancer (genetics), Nucleotide, Ligand (biochemistry), Post-translational modification, Result, Conformational change, Cooperativity, Structural biology, Adrenergic receptor, Acid–base homeostasis, Biology, Hemoglobin, Proofreading (biology), Bohr effect, Chemoreceptor, Biophysical chemistry, Cryo-electron microscopy, Gillespie algorithm, Repressor, Transcription factor, Enzyme, Statistical physics, Gene expression, Sequencing, Binding constant, Autoinducer, Phosphofructokinase, Phosphodiesterase, Quorum sensing, Action potential, Protein, Hill equation (biochemistry), Allosteric enzyme, Optical tweezers, Receptor (biochemistry), Anaphase, Chromatin, Kinetic proofreading, EC50, Calculation, Ion channel, Inducer, Polymerase, Michaelis–Menten kinetics, Probability