Androgen-Responsive Genes in Prostate Cancer

Regulation, Function and Clinical Applications

Zhou Wang (Hrsg.)

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ca. 192,59
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Springer New York img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Nichtklinische Fächer

Beschreibung

Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males.  AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes.  Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer.   This volume provides critical information from  well respected experts in the field.  Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT).  Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function.  This book is intended for researchers, scientists, faculty, and advanced graduate students  with an interest in androgen action and prostate cancer.​  

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Schlagwörter

chromatin looping, miR-21, prostate tumorigenesis, androgen receptor coregulators, androgen action