The Future of HIV-1 Therapeutics
Bruce E. Torbett (Hrsg.), Douglas D. Richman (Hrsg.), David S. Goodsell (Hrsg.)
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Springer International Publishing
Naturwissenschaften, Medizin, Informatik, Technik / Mikrobiologie
Beschreibung
This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.
Kundenbewertungen
HIV protease, Human immunodeficiency virus, HIV Gag protein, HIV integrase protein, HIV matrix, HIV-1 latency, Fragment-based drug design, HIV reverse transcriptase protein, HIV stem-loop, HIV-1 drug resistance, High-throughput virtual screening, HIV capsid, HIV-1 illustrations, Tat/TAR/P-TEFb complex, Rev protein, HIV transcription, LEDGF/p75 protein, Structure-based drug design, HIV-1 antiretroviral treatment, HIV nucleocapsid protein, antibacterial drug resistance