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Quantifying Interactions of Biomolecules with Inorganic Surfaces

Abhijeet Patra

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Springer International Publishing img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Atomphysik, Kernphysik

Beschreibung

This thesis demonstrates the adaptation of existing techniques and principles towards enabling clean and precise measurements of biomolecules interacting with inorganic surfaces. In particular, it includes real-time measurement of serum proteins interacting with engineered nanomaterial. Making meaningful and unambiguous measurements has been an evolving problem in the field of biology and its various allied domains, primarily due to the complex nature of experiments and the large number of possible interferants. The subsequent quantification of interactions between biomolecules and inorganic surfaces solves pressing problems in the rapidly developing fields of lipidomics and nanomedicine.

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Schlagwörter

Nanoparticle-Based Drug Screening, Serum Protein Interactions, Protein Corona, Nanoscale Wettability, Lipid Fraction Enrichment, Surface Plasmon Resonance