Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
Stacey L. McDonald
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Springer International Publishing
Naturwissenschaften, Medizin, Informatik, Technik / Organische Chemie
Beschreibung
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
Kundenbewertungen
C–N Bond Formation, C–H Functionalization, Copper-Catalyzed Amination, Aryl Amines, Electrophilic Amination, Alpha-Aminophosphonic Acids