Tumor Organoids

Shay Soker (Hrsg.), Aleksander Skardal (Hrsg.)

PDF
ca. 166,59
Amazon iTunes Thalia.de Weltbild.de Hugendubel Bücher.de ebook.de kobo Mayersche Osiander Google Books Barnes&Noble bol.com
* Affiliatelinks/Werbelinks
Hinweis: Affiliatelinks/Werbelinks
Links auf reinlesen.de sind sogenannte Affiliate-Links. Wenn du auf so einen Affiliate-Link klickst und über diesen Link einkaufst, bekommt reinlesen.de von dem betreffenden Online-Shop oder Anbieter eine Provision. Für dich verändert sich der Preis nicht.

Springer International Publishing img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Nichtklinische Fächer

Beschreibung

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Weitere Titel zum gleichen Preis
Cover Head and Neck
Enrico Marani
Cover DJ-1/PARK7 Protein
Sanae M. M. Iguchi-Ariga
Cover The Plastic Brain
Rommy von Bernhardi
Cover Personalised Medicine
Sherif El-Khamisy

Kundenbewertungen

Schlagwörter

Anti-Cancer, Stroma, Organoids, 3-D Human Tissue, Drug Development, In Vivo, Tumor