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Acute and Chronic Neural Stimulation via Mechano-Sensitive Ion Channels

Andy Kah Ping Tay

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Springer International Publishing img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Sonstiges

Beschreibung

This book describes the tools, developed by the author, for perturbing endogenous mechano-sensitive ion channels for magneto-mechanical neuro-modulation. He explores the ways in which these tools compare against existing ones such as electricity, chemicals, optogenetics, and techniques like thermos/magneto-genetics. The author also reports on two platforms—magnetic ratcheting and magnetic microfluidics for directed evolution and high throughput culture of magnetotactic bacteria—that produce high quality magnetic nanoparticles for biomedical applications like neural stimulations. This thesis was submitted to and approved by the University of California, Los Angeles.

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Schlagwörter

Biomechanical forces, Brain folding, Gene expression and calcium influx, Synapses and neurotransmitter release, Circuitry and plasticity, Neurite growth, Traumatic brain injury, Magnetic nanoparticle synthesis, Microfluidic bioreactor, Cellular functions