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Microwaves in Organic and Medicinal Chemistry

C. Oliver Kappe, Alexander Stadler

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Wiley-VCH img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Organische Chemie

Beschreibung

The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.

Rezensionen

Organic Process Research & Development
"This is a well thought out and nicely constructed book which has been carefully written with its audience in mind. It is more than just a literature review, it is a handbook of "how to do it", which will be extremely useful to the practitioner. In my view, this is now the seminal text for chemists (especially, but not exclusively, medicinal chemists) using microwaves on laboratory scale. I can warmly recommend this book, and would expect it to end up on the shelves in most synthetic organic laboratories."
ChemMedChem
"...this easy to read work is essential for chemists wishing to learn about the state of the art in microwave-assisted organic synthesis chemistry and will be a handy reference volume for more experienced microwave chemists."
Journal of Medicinal Chemistry
"This eight-chapter monograph provides a broad overview of the area with sufficient detail to guide the inexperienced user and enough breadth to satisfy the experienced organic and medical chemist. This well-written book can be viewed as consisting of three parts: background/theory, reagents/equipment, and literature overview. (...) Overall, the text is very well written. The references are very current, and the 'how to' sections are clear. This book definitely speaks to its audiences at just the right levels for each. (...) There is a lot of very practical information in this book to recommend it for inclusion in both industrial and academic libraries."
Chemistry World
"...Microwaves in organic and medicinal chemistry provides a superb reference tool for any interested chemist using, or thinking of using, microwave assisted organic synthesis on an occasional or regular basis. The text is clear, well-written and gives an authoritative discussion of the field. It misses little in the way of technical or chemical detail ... For the beginner or a microwave regular, this book provides an excellent outline of the state of play in this field. ....this is the place to look...a very enjoyable and interesting book, revealing that no question is too silly to ask."
Angewandte Chemie IE
"The book is very well laid out and presented. The schemes are excellent and the photographs very clearly reproduced. The index is well put together and it is easy to find specific reactions. In summary, this book is general enough to be useful to chemists new to the field as well as proving a valuable resource to those who already use microwave heating in their chemistry, and I certainly recommend it to both."
Archiv der Pharmazie
"In summary, this monograph is well-written by experts in the field. Since all chapters are written by the same authors, redundant recurrences are omitted and helpful cross links are supplied. The book is logically organized and easy to read. While the experienced user will find many interesting hints, details and references, the beginner will profit from vivid explanations and practical advice. As an invaluable source of information for every chemist interested in microwave assisted organic chemistry, the book is recommended to the library of every chemistry department."
Carbohydrate Polymers
"This book is an indispensable information source for organic and medicinal chemists in academia, as well as those in the chemical and the pharmaceutical industry. It provides the reader a well-structured, up-to-date, and exhaustive overview of known synthetic procedures involving the use of microwave technology. Some chapters of this book are sufficiently convincing as to encourage scientists not only to use microwave synthesis in their research, but also to offer training for their students and co-workers."
CHOICE
"...this book contains many pertinent examples for chemists working in distinct areas such as discovery research or process development."
Nachrichten aus der Chemie
"Insgesamt ist dieses Buch also uneingeschränkt als ein zuverlässiges Lehrbuch und Nachschlagewerk für Chemiker in Industrie- und Hochschullabors zu empfehlen."
Angewandte Chemie
"Das Buch ist sehr ansprechend aufgemacht, und auch das Bildmaterial ist ausgezeichnet. Das Stichwortverzeichnis ist ausführlich und sehr nützlich zum Auffinden bestimmter Reaktionen. Was die inhaltliche Darstellung betrifft sind die Ausführungen einerseits allgemein genug, um Neulingen den Einstieg in das Gebiet zu erleichtern, andererseits aber auch hinreichend detailliert, um erfahrenen Anwendern eine sehr nützliche Informationsquelle an die Hand zu geben. Beiden Zielgruppen kann die Lektüre wärmstens empfohlen werden."
BioTec
"Eine sehr gute Einführung und einen umfassenden Literaturüberblick über diese neue Synthesetechnologie liefern die beiden Autoren in ihrem vorliegenden Werk. ... Wer organisch-chemisch im Labor tätig ist, wird an Mikrowellen nicht vorbeikommen und hier einen passenden...Einstieg finden."
PharmaTec
"Die erfahrenen Autoren fokussieren sich in diesem Buch auf allgemeine Reaktionsarten in der medizinischen Chemie, einschließlich der festen Phasen und kombinatorischen Methoden. Es berücksichtigt die grundlegende Theorie, die neuesten Entwicklungen in der Mikrowellen-Anwendung und beinhaltet eine Vielfalt von Beispielen über die neueste Literatur."
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Schlagwörter

Organische Chemie, Pharmazeutische u. Medizinische Chemie, Chemie, Organic Chemistry, Pharmaceutical & Medicinal Chemistry, Technische u. Industrielle Chemie, Industrial Chemistry, Chemische Technik, Chemistry, Medizinische Chemie