MRI Contrast Agents

From Molecules to Particles

Robert N. Muller, Céline Henoumont, Luce Vander Elst, et al.

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Springer Singapore img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Medizin

Beschreibung

This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc. 

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Schlagwörter

Nanotheranostics, Nanomaterials in Medicine, Nanoparticular Systems, Nanoparticles in Imaging, Imaging Probes, Supramolecular Systems, MRI Contrast Agents, Superparamagnetic Contrast Agents, Iron Oxide Nanoparticles, Paramagnetic Gadolinium Complexes