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Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches
Daniel Yuan Qiang Wong
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Naturwissenschaften, Medizin, Informatik, Technik / Physikalische Chemie
Beschreibung
This thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these “secret allies” contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immuneresponses to malignancies, eliminating residual cancer cells.
Kundenbewertungen
Chemotherapeutic Platinum Complexes, Cisplatin Prodrugs, Chemoselective Imine Ligation, Immuno-Modulation by Platinum-based Complexes, Platinum(IV) Prodrugs, Targeted Necrosis, Multimodal Anticancer Agents, HER2-Targeted Platinum(IV) Anticancer Prodrugs, Platinum(IV) Prodrug Scaffold, Platinum(IV)-Peptide Conjugates