Development of Antibody-Based Therapeutics

Translational Considerations & Challenges

Gadi G. Bornstein (Hrsg.), Scott L. Klakamp (Hrsg.), Mohammad A. Tabrizi (Hrsg.)

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Springer Singapore img Link Publisher

Naturwissenschaften, Medizin, Informatik, Technik / Pharmazie

Beschreibung

With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. 
This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.

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Schlagwörter

Bi-specific constructs, Preclinical studies, Dosing strategy, Cross-reactivity, Pharmacokinetics, Immune-oncology, Pharmacodynamics, Immune system, Nanobodies, First-in-human dosing, Design criteria, Biophysical characterization, Combination therapies, Cancer, Relevant species, Monospecific concepts, Biomarkers