Structural Aspects of Protein Synthesis
Anders Liljas, Måns Ehrenberg
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Naturwissenschaften, Medizin, Informatik, Technik / Biochemie, Biophysik
This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases.Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.Contents:The Basics of TranslationHistorical MilestonesMethods of Studying StructureThe Message — mRNAThe Adaptor — tRNAThe Workbench — RibosomesThe Structure of the RibosomeRibosomal Sites and Ribosomal StatesThe Catalysts — Translation FactorsInhibitors of Protein Synthesis — Antibiotics, ResistanceThe Process — TranslationProtein Processing, Folding and TargetingEvolution of the Translation ApparatusReadership: Upper level undergraduates and graduate students with an interest in protein synthesis; researchers in cell and molecular biology, biochemistry and biophysics who need to get an overview of translation.