Crystallization of Organic Compounds
James A. McCauley, Hsien-Hsin Tung, Edward L. Paul, et al.
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Naturwissenschaften, Medizin, Informatik, Technik / Chemie
Filled with industrial examples emphasizing the practicalapplications of crystallization methodologies Based on the authors' hands-on experiences as process engineersat Merck, Crystallization of Organic Compounds guidesreaders through the practical aspects of crystallization. It usesplenty of case studies and examples of crystallization processes,ranging from development through manufacturing scale-up. The booknot only emphasizes strategies that have been proven successful, italso helps readers avoid common pitfalls that can render standardprocedures unsuccessful. The goal of this text is twofold: * Build a deeper understanding of the fundamental properties ofcrystallization as well as the impact of these properties oncrystallization process development. * Improve readers' problem-solving abilities by using actualindustrial examples with real process constraints. Crystallization of Organic Compounds begins with detaileddiscussions of fundamental thermodynamic properties, nucleation andcrystal growth kinetics, process dynamics, and scale-upconsiderations. Next, it investigates modes of operation, includingcooling, evaporation, anti-solvent, and reactive crystallization.The authors conclude with special applications such as ultrasoundin crystallization and computational fluid dynamics incrystallization. Most chapters feature multiple examples that guidereaders step by step through the crystallization of activepharmaceutical ingredients (APIs). With its focus on industrial applications, this book isrecommended for chemical engineers and chemists who are involvedwith the development, scale-up, or operation of crystallizationprocesses in the pharmaceutical and fine chemical industries.
"For chemists and engineers working in process research and development, or even in production, this is the best book on crystallisation. For those in other disciplines, or in academia, wishing to get a perspective on industrial problems in crystallisation, polymorphism, salt formation etc and how to solve them, this would also be a valuable book . . . I think they have achieved both of these goals admirably, and in a very readable and enjoyable format."
Chemistry, Wirkstoffforschung u. -entwicklung, Chemie, Verfahrensentwicklung, Chemical Engineering, Drug Discovery & Development, Chemische Verfahrenstechnik, Process Development