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Development and Validation of Differential Spectrophotometric Method for Assay of Enrofloxacin in Bulk and Tablet Formulation
M. Patel
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Naturwissenschaften, Medizin, Informatik, Technik / Pharmazie
Beschreibung
Research Paper (postgraduate) from the year 2019 in the subject Medicine - Pharmacology, Pharmacy, , course: M pharmacy, language: English, abstract: A simple, precise and accurate spectrophotometric method have been developed and validated for the estimation of Enrofloxacin in bulk as well as tablet formulation. The UV spectra of Enrofloxacin was obtained in 0.1N HCl and 0.1N NaOH, and the overlain spectra showed maximum absorbance at 271.0 nm (maxima) and 276.5 nm (minima) in 0.1N NaOH and HCl respectively. The drug follows linearity in the range of 5-30 µg/ml (R2= 0.988). Both intra- and inter-day precision showed % RSD˂ 2 while LOD and LOQ were 0.320 and 0.971 respectively. The method was validated as per ICH guidelines. Enrofloxacin or [1-cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3 quinoline carboxylic acid]. The chemical structure of the drug is given in. It is a synthetic antibacterial agent from the class of the fluroquinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria. Enrofloxacin is used for the treatment of individual pets and domestic animals. Literature survey shows that several analytical methods for the determination of Enrofloxacin include RP-HPLC, HPLC, RP-LC, LC and dissolution study have been reported. Many pharmaceutical products have been assayed by this method. But Differential UV spectrophotometric method of Enrofloxacin was not reported as so far. So an attempt was made to develop a novel, simple, accurate spectrophotometric method for the determination of Enrofloxacin in tablet formulation.
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Differential UV Spectrophotometry, Enrofloxacin Tablet Analysis., ICH, Validation, Enrofloxacin